The dark proteome of HIV-1 and T cell immunity

Ort: Gebäude E 8.1 (HIPS), Seminarraum EG, 66123 Saarbrücken

Gemeinsame Veranstaltung im Rahmen des Deutsch-Französischen Diskurses mit der Universität des Saarlandes

Abstract

T lymphocytes control the infection with human immunodeficiency virus-1 (HIV). Their activation depends on the recognition of antigens, thought to derive from classical HIV proteins. The talk will present the mapping of the HIV-1 "translatome", i.e., the identification of all HIV-1 mRNA sequences that are translated into proteins. The data show that the HIV-1 genome contains about 100 alternative reading frames (ARFs), located either upstream of the genes encoding classic viral proteins or overlapping the main coding regions of HIV. Thus, HIV encodes newly identified antigens capable of inducing broad and potent T-cell responses that could be used in vaccine design.

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Professor Dr. Alexandra K. Kiemer
Vorsitzende der DPhG Landesgruppe Saar