Understanding the impact of sex on immunity in the bladder

Gebäude E 8.1 (HIPS), Seminarraum EG, 66123 Saarbrücken

Understanding the impact of sex on immunity in the bladder
Prof. Dr. Molly Ingersoll (Institut Pasteur in Paris)

Abstract

Our group is interested in understanding how biological sex influences mucosal immunity. To study this, we use mouse models of bladder diseases and human cohorts. Urinary tract infections are profoundly sex-biased, impacting nearly 50% of all women but only 5-10% of men. Our recent work demonstrates that IL-17, which varies between the sexes, is a critical player in resolution of infection. We also identified antigen-specific tissue-resident T cells in the bladder that are necessary and sufficient for protection against recurrent infection and are divergent between the sexes. We are now determining how these responses can be immunomodulated for improved therapeutics that obviate the need for antibiotics to treat multidrug resistant uropathogens.

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Professor Dr. Alexandra K. Kiemer
Vorsitzende der DPhG Landesgruppe Saar